A Collection of Kratom & Alkaloid Science
At Socratic Solutions, we believe in science and the Socratic method. As retailers of kratom products we also feel that it is our responsibility to stay informed about the product we offer. Part of that responsibility is kratom research, which we believe should be shared always to encourage intelligent discussion and informed decision making.
The following is a live collection of research data that we uncovered through the censored search results, fake news, and incessant propaganda. Specifics vary, but all pieces discuss kratom as a whole or its individual alkaloids. We try our best to keep only credible information here, but please let us know of any retractions if you see any.
In some cases we can not link to a full text version of the article due to access restrictions. To read these articles in full, please paste the DOI number into Sci-Hub (science should not be hidden behind a paywall or limited to your institutional or corporate affiliations). We will add to this as we locate more credible pieces of information.
- Herbal remedies for treatment of hypertension
- Risk of death associated with kratom use compared to opioids
- Abuse liability of mitragynine assessed with a self-administration procedure in rats
- Mitragyna speciosa: A systematic review of its pharmacology and survey of its use in the Northern States of Malaysia
- Evaluation of the rewarding effects of mitragynine and 7‐hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats
- Alkaloid Profiles and Activity in Different Mitragyna speciosa Strains
- Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)
- Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
- Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing’s sarcoma and breast cancer cell lines
- Kratom (Mitragyna speciosa): User demographics, use patterns, and implications for the opioid epidemic
- Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review
- Discriminative stimulus properties of mitragynine (kratom) in rats
- Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: kratom abuse liability
- Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom
- Is kratom (Mitragyna speciosa Korth.) use associated with ECG abnormalities? Electrocardiogram comparisons between regular kratom users and controls
- Kratom Scientist Letter to House and US Senate Leadership
- The abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research
- High serum high-density lipoprotein and low serum triglycerides in Kratom users: A study of Kratom users in Thailand
- Lipid profile of regular kratom (Mitragyna speciosa Korth.) users in the community setting
- The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats
- The Potential for Kratom as an Antidepressant and Antipsychotic
- Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” (Mitragyna speciosa) by LC-ESI-MS
- Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E₂ production induced by lipopolysaccharide in RAW264.7 macrophage cells
- Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine
- Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
- The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
- 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
- Effect of Mitragyna speciosa aqueous extract on ethanol withdrawal symptoms in mice
- Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems
- Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence
- Anti-Inflammatory and Antinociceptive Effects of Mitragyna speciosa Korth Methanolic Extract
- Determination of Alkaloids in Mitragyna speciosa (Kratom) Raw Materials and Dietary Supplements by HPLC-UV: Single-Laboratory Validation, First Action 2017.14
- Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats
- Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts from Mitragyna Speciosa (Rubiaceae Family) Leaves
- Kratom policy: The challenge of balancing therapeutic potential with public safety
- Pharmacology of Kratom: An Emerging Botanical Agent With Stimulant, Analgesic and Opioid-Like Effects
- Kratom and Other Mitragynines | The Chemistry and Pharacology of Opioids from a Non-Opium Source
- Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark
- Quantitative Analysis of Mitragynine in Consumer Products Labeled as Kratom
- Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia
- Gastroprotective effects of methanolic extract of kratom leaves on gastric ulcer and reflux esophagitis in rats
- Behavioral and neurochemical characterization of kratom (Mitragyna speciosa) extract
- Neurobiology of Kratom and its main alkaloid mitragynine
- Experiences of Kratom Users: A Qualitative Analysis
- Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
- Kratom in Thailand | Decriminalisation and Community Control?
- Chemical constituents and nitric oxide inhibitory activity of supercritical carbon dioxide extracts from Mitragyna speciosa leaves
- Pharmacokinetics of mitragynine in man
- Patterns of Kratom use and health impact in the US-Results from an online survey
- Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats
- An Evidence-Based Systematic Review of Kratom ( Mitragyna speciosa) by the Natural Standard Research Collaboration
- Current perspectives on the impact of Kratom use
- Mitragyna speciosa Leaf Extract Exhibits Antipsychotic-Like Effect with the Potential to Alleviate Positive and Negative Symptoms of Psychosis in Mice
- Methanolic extract of Mitragyna speciosa Korth leaf inhibits ethanol seeking behaviour in mice: involvement of antidopaminergic mechanism
- Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal
- Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism
- List Of Alkaloids Identified In Mitragyna Speciosa Kratom | Kratom Science
- Pharmacokinetics and Safety of Mitragynine in Beagle Dogs
- Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine
- Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids
“There is a general consensus among community members and leaders, academics and policymakers, as well as public health and law enforcement representatives in southern Thailand that kratom use and dependence carry little, if any, health risks. In general, people reported that kratom (use and dependence) is less harmful than heroin, yaba, cannabis and even alcohol,”
– Pascal Tanguay International Drug Policy Consortium (IDPC)
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.
