UPDATED MARCH 26. 2020
Journal article of reference: https://www.frontiersin.org/articles/10.3389/fphar.2016.00464/full#B23
I came across an interesting article the other day from the December 6th, 2016 (volume 7) issue of Frontiers in Pharmacology. This is a peer-reviewed journal, and I try to use those as confirmation of pretty much anything I read on the internet or anywhere else really. Having a team of other published researchers in the same field approve a piece before it is published makes the data more credible. This particular study piqued my interest because, among the many other lies, our government agencies have claimed that kratom causes psychosis.
This particular study attempted to compare mitragyna speciosa to typical antipsychotics (like haloperidol) and atypical antipsychotics (like risperidone) as a potential treatment option for subjects suffering from psychosis. If effective, the big benefit would be that mainstream antipsychotic drugs are associated with lots of side effects; some of them serious and some potentially fatal. Keep in mind these drugs are approved by the FDA.
Side Effects of Traditional Antipsychotic Medications
I figure the best way to do it would probably be to start with a brief list of known adverse effects of mainstream antipsychotics (Dalpoas et al., 2018):
- Antipyramidal effects: dystonia (neurological condition that can leave users’ limbs literally stuck in weird positions), akathisia (uncontrollable restlessness), Parkinson’s-like symptoms, and others (Macallis, 2013)
- Metabolic Syndrome, a/k/a Syndrome X: this is a collection of symptoms including elevated lipid profiles (insoluble fat in the blood that can clog arteries), insulin resistance (precursor to type 2 diabetes), increased fat around the midsection, abnormally high LDL levels (the bad type of cholesterol), high blood pressure, and low HDL levels (the good kind) (Eckel et al., 2005).
- Anti-cholinergic effects: dysfunction of the parasympathetic nervous system (involuntary muscle movements such as in digestion or bowel motility), confusion, blurred vision, and more (Greenblatt & Shader, 1973)
- Orthostatic hypotension: feeling lightheaded upon standing, fainting (Mayo Clinic Staff, 2017)
- Hyperprolactinemia: effects include loss of libido, lactation in both males and females, and infertility (Sawyers, 2018)
- Elevated readings from liver function tests, hepatitis
In The Real World
Let’s take a drug called Haloperidol for example. Haldol, which is the drug’s trade name, is known to cause tardive dyskinesia (a serious neurological condition involving uncontrollable movements all over the body) and neuroleptic malignant syndrome, which is a life threatening condition involving unstable blood pressure, stupor, and loss of autonomic function (Caroff et al., 2011).
It’s not like this is top-secret knowledge, either. This delightful excerpt was taken right from the FDA’s own database: “Cases of sudden death, QT-prolongation, and Torsades de Pointes have been reported in patients receiving HALDOL” (Ortho-McNeil Pharmaceutical, Inc., 2005). Atypical antipsychotic drugs are associated with transient ischemic attacks (TIAs), metabolic syndrome, tardive dyskinesia, and an increased risk of diabetes, among other things (College of Psychiatric and Neurologic Pharmacists, 2018).
Details of the Study
In the study, which was first published in the December 2016 version of Frontiers in Pharmacology, the research team created a kratom solution using methanol as the base solvent and gave it to apomorphine-induced mice to see how well the solution performed in this standard test. Apomorphine is a dopamine receptor agonist often used to treat Parkinson’s but in this case used to manufacture psychotic episodes (Zarrindast et al., 2000). The kratom solution not only decreased the psychotic behavior of the mice, but it also improved catalepsy (muscle rigidity and limbs often being “stuck” in odd positions) in other mice that had been treated with haloperidol.
This conclusion was that mitragyna speciosa somehow regulates dopaminergic neurotransmission in the brain regions associated with psychosis. It was also shown to alleviate the symptoms of ketamine-induced social withdrawal. There was no mention of any adverse effects from the kratom concoction.
UPDATE: MARCH 26, 2020: More evidence of the above has been discovered along with case studies showing kratom’s potential as an anti-depressant and mitigation tool in other mental health conditions. This post will be under constant update until I get all of the information here for you.
Further studies would be great to further qualify kratom’s antipsychotic potential. Research will go on as long as kratom remains decriminalized. Even if they do take away our right to use kratom, perhaps by turning its components into controlled, profitable, prescription medications, it’s safe to say that we will continue learning about it moving forward. The venue may just change a bit, that’s all.
So what’s the moral of the story? Your morning Green Malay your evening Red Maeng Da, or your Friday night Yellow Thai kratom is not going to make you go crazy, no matter how hard they try to convince you. In fact, it will probably help you if you’re already crazy :)!
This is only one study, but there are more data from the field out there that help validate it. Google Scholar (https://scholar.google.com) is one source of credible information, though you need to pay attention to who funds studies and who is to benefit from the potential results as these things create an automatic bias. There’s also the Directory of Open Access Journals (https://doaj.org), which can give you a good starting point. Remember: think critically!
Caroff, S. N., Hurford, I., Lybrand, J., & Campbell, E. C. (2011). Movement Disorders Induced by Antipsychotic Drugs: Implications of the CATIE Schizophrenia Trial. Neurologic Clinics, 29(1), 127–viii. Retreived March 24, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018852/
Dalpoas, S. E., Peters, M. E., & Marano, C. (2018, December 3). Antipsychotics | Johns Hopkins Diabetes Guide. https://www.hopkinsguides.com/hopkins/.//view/Johns_Hopkins_Diabetes_Guide/547011/all/Antipsychotics?refer=true
Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. (2005). The metabolic syndrome. The Lancet, 365(9468), 1415–1428. https://doi.org/10.1016/S0140-6736(05)66378-7
Greenblatt, D. J., & Shader, R. I. (1973). Anticholinergics. New England Journal of Medicine, 288(23), 1215–1219. https://doi.org/10.1056/NEJM197306072882306
Macallis. (2013, November 13). 2.1: Extrapyramidal symptoms | Antipsychotic Agents. UNC Eshelman School of Pharmacy. https://learn.pharmacy.unc.edu/antipsy/node/39
Mayo Clinic Staff. (2017, July 11). Orthostatic hypotension (postural hypotension)—Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/orthostatic-hypotension/symptoms-causes/syc-20352548
Ortho-McNeil Pharmaceutical, Inc. (2005). HALDOL ® brand of haloperidol injection (For Immediate Release). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/015923s082,018701s057lbl.pdf
Sawyers, T., & Riggins Nwadike, MD, MPH, V. (2018, November 20). Hyperprolactinemia: Causes and Symptoms. Healthline. https://www.healthline.com/health/hyperprolactinemia
Zarrindast, M.-R., Fazli-Tabaei, S., Semnanian, S., Fathollahi, Y., & Yahyavi, S. H. (2000). Effects of Adrenoceptor Agents on Apomorphine-Induced Licking Behavior in Rats. Pharmacology Biochemistry and Behavior, 65(2), 275–279. https://doi.org/10.1016/S0091-3057(99)00198-7